Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Common side effects of (duloxetine) Cymbalta include nausea, dry mouth, drowsiness, insomnia, and sexual dysfunction. Your provider may recommend a different time to take your medication, drinking plenty of fluids, and other methods for managing side effects. Learn about the side effects of duloxetine, from common to rare, for consumers and healthcare professionals. Cymbalta is a depression and anxiety medication. Here are 13 side effects to know before taking Cymbalta and when to consult your prescriber. Cymbalta can cause sexual side effects, including decreased sexual desire in both men and women, delayed or no orgasm in women, and delayed ejaculation in men. What are the most common side effects of duloxetine? The most common side effects of duloxetine are listed below. Tell your healthcare provider if you have any of these side effects. Cymbalta, which is used to treat depression, can cause side effects. Learn about its more common, mild, and serious side effects and how to manage them. Common side effects of Cymbalta include nausea, dry mouth, constipation, diarrhea, fatigue, difficulty sleeping, and dizziness, and sexual dysfunction. Consult your doctor before taking Cymbalta if pregnant or breastfeeding. Nausea, dry mouth, and fatigue are often most noticeable during the first few weeks and may lessen over time. However, some side effects may last longer or return after dose increases. If you experience severe, persistent, or worsening symptoms, you should be evaluated by a healthcare professional. See also: Rexulti View more Examples of more common side effects of Cymbalta include nausea, dry mouth, constipation, drowsiness, and sexual side effects like decreased libido or delayed orgasm. Serious side effects of.